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Why do I experience the symptoms of a hangover?

Alcohol and its metabolites are toxins. You experience the symptoms of a hangover because your alcohol intake exceeded the pace at which your liver was able to neutralize the alcohol you ingested, plus, your system isn’t able to deal with the more potent toxins that came from the alcohol as it was being metabolized, especially acetaldehyde. Therefore, other factors [“What is the main cause of a hangover”] besides the ethanol in an alcoholic beverage cause the symptoms of a hangover. Don’t like hangovers? Neither do we. You have two options: drink less alcohol or support your body’s natural effort to metabolize alcohol while you’re drinking, as well as after you’ve finished drinking. Drinking less alcohol is self-explanatory. See the information below outlining other actions you can take that will help.

What is the main cause of a hangover?

Contrary to popular belief, the alcohol you consume is not the immediate cause of the hangover symptoms you experience. For most people, about 20 percent of the alcohol consumed is absorbed rather quickly by the stomach, while the remaining 80 percent is largely absorbed by the intestines. A small portion “escapes” altogether and passes through your body without being absorbed. The amount of alcohol you absorb through your stomach will vary with the amount of food in your stomach at the time; that is, more food in your stomach equals slower absorption of alcohol. As the alcohol absorbed by your stomach begins circulating in your blood, your liver begins metabolizing the alcohol by converting it into acetaldehyde. The alcohol absorbed by your intestines follows the same pattern, but gets a slightly later start on the same process. While it is never good to flood the liver with alcohol, the liver is able to do its “first pass” work of metabolizing the alcohol in your bloodstream fairly quickly. The first time that alcohol goes through the liver it is converted into acetaldehyde, which is approximately 30 times more toxic than the alcohol itself. This is where the hangover battle begins. Obviously, the more you drink, the more alcohol there is in your system, and so more acetaldehyde is created as the liver metabolizes that alcohol. Acetaldehyde, because of its extraordinarily high level of toxicity, immediately starts damaging your body in multiple ways. If your liver were able to produce a tripeptide called glutathione more quickly, then the liver could do a better job of metabolizing the acetaldehyde and converting it into less harmful substances like acetic acid, thus reducing the hangover symptoms that inevitably follow a night of drinking. But because the liver produces glutathione so slowly, the body falls behind in the metabolism of acetaldehyde to acetic acid. Hence, acetaldehyde builds up as a person continues to drink, and the magnitude of hangover symptoms grows accordingly. If you’ve noticed that hangover symptoms can last a full day after drinking, that’s because it can take that long for the liver to produce enough glutathione to clear the acetaldehyde from your body. Of particular concern, excessive alcohol consumption and the accompanying decreased clearance of acetaldehyde can lead to widespread damage in the body. [“What are these toxins doing to my body?”] An excellent alternative is to use highly absorbable Zero Hour Detox™ to deliver glutathione – which your body can’t produce fast enough on its own – at the exact time your body needs it: when you are drinking and immediately afterward.

What are the most common hangover symptoms?

The most common symptoms (which can often be extreme) of a hangover are headache, nausea, abdominal pain from the excess production of stomach acids, dizziness, full body pain, loss of appetite, thirst, and fatigue. These symptoms arise because acetaldehyde is circulating in your body for hours – due largely to a glutathione shortage in the liver – and continues to attack and damage cells. Acetaldehyde rather easily passes the blood-brain barrier, which creates that wrecking ball feeling in your head and exacerbates all of its other symptoms. NOTE: While Zero Hour Detox™ can help moderate drinkers and those sensitive to alcohol dramatically greatly reduce some of these common symptoms,* Zero Hour Detox™ cannot eliminate thirst if you are poorly hydrated, nor can Zero Hour Detox™ eliminate fatigue if you were up all night! Some things you need to do on your own – so drink plenty of water and get as much sleep as possible.

What are these toxins doing to my body?

Brace yourself, because it’s not pretty. But we want our customers to understand how important the glutathione is in Zero Hour Detox™ by explaining the damage done by excessive alcohol consumption and its related toxins, like acetaldehyde, when those toxins are not quickly cleared from the body.*

  • Liver Damage

    The liver is the major metabolic organ of the body – it not only processes nutrients from the gastrointestinal tract, it also detoxifies harmful chemicals by metabolizing them into their water-soluble forms so they may be easily excreted from the body in the urine. Unfortunately, overtaxing the liver’s detoxification process can result in liver damage, either directly from exposure to the alcohol itself or from the subsequent alcohol metabolites formed during detoxification. Acetaldehyde is a very reactive molecule, which makes it very capable of binding to proteins that form harmful modifications that can cause serious damage to brain and liver tissue. The metabolic breakdown of alcohol into acetaldehyde is an oxidation reaction that changes chemical states in the body. Gluconeogenesis – the metabolic production of glucose from non-carbohydrate sources – is prevented by the accumulation of fatty acids resulting from accelerated fatty acid synthesis. This leads to fat being deposited in the liver, which can eventually lead to the condition known as “fatty liver,” a condition not easily visible until its later stages. The next stage in liver disease is hepatitis, which is characterized by widespread liver inflammation and the subsequent development of necrosis and scar tissue formation. The inflammation is a result of the over-production of inflammatory mediators in response to liver tissue damage. Long-term consumption of alcohol stimulates the liver cells to produce collagen, which is a primary component of scar tissue. Liver functionality is lost as healthy tissue becomes replaced with scar tissue. Finally, cirrhosis of the liver is characterized by fibrosis to such an extent that blood vessels passing through the liver are constricted so seriously that the liver’s structure and function is altered. And cirrhosis causes a vicious circle as increased alcohol intake causes increased liver damage because the liver is less and less able to metabolize the alcohol, thus worsening and prolonging alcohol’s damaging effects.

  • Central Nervous System Damage

    Behavioral Effects Immediate behavioral effects include slurred speech, impaired reflexes and reaction times, unsteadiness, disorientation, confusion, and emotional disturbances. Neurotransmitters Glutamate: Alcohol impairs the function of the brain’s primary excitatory neurotransmitter, glutamate. Impairment of glutamate neurotransmission can alter learning and memory. The decreased activity of glutamate caused by alcohol can also cause a “rebound effect,” which increases the risk of seizures and neuronal cell death via neurotoxicity. GABA: The brain’s primary inhibitory neurotransmitter, GABA (gamma-aminobutyric acid), is also adversely affected by alcohol. Alcohol impairs GABA in concert with the connection between GABA and glutamate. GABA and glutamate are counterbalanced under normal circumstances with regulatory networks that balance the relative abundance of GABA and glutamate-related neurotransmission. Imbalances lead to a seesaw effect – too much GABA and not enough glutamate leaves the brain in a depressed state, impairing cognitive abilities associated with alcohol intoxication. Alcohol also has adverse effects on other brain neurotransmitters such as dopamine and serotonin. Chronic alcohol use can cause brain atrophy and structural changes, and can even lead to alcoholic dementia, such as Wernicke-Korsakoff syndrome.

  • Heart Damage

    Alcohol consumption in large quantities can lead to arrhythmias (irregular heart beat), and even smaller amounts can lead to increased heart rate (tachycardias). Long-term overuse of alcohol can damage the heart muscle, increase blood pressure, cause hypertrophy of the heart (enlarged heart muscle), and increase the risk of coronary artery disease and hypertension.

  • Blood Effects

    Alcohol depletes the body of the B vitamins, including thiamine (vitamin B1), which is linked to Wernicke-Korsakoff syndrome in chronic alcohol abuse and alcoholism. Alcohol also disrupts red blood cell production via its toxic effect on bone marrow function, which is why prolonged alcohol use is often associated with the increased risk of anemia.

  • Gastrointestinal Damage

    Alcohol can damage the esophagus, which increases the risk of chronic heartburn. This often leads to nutritional disturbances such as malabsorption and weight loss, an increased risk of mouth, throat, and stomach cancers, and altered intestinal permeability.

  • Other Damage

    Alcohol abuse can cause adverse effects on the reproductive system, in both men and women, such as infertility and miscarriage. The immune system suffers from disruption of white blood cell function. By the immune system becoming less functional, it can lead to increased risks of infection and delayed wound healing. Other potential health risks include damage to the pancreas (pancreatitis), osteoporosis, and psychological factors, such as depression and anxiety.

How can I reduce hangover symptoms?

That’s easy – drink less alcohol. The fewer toxins you put in your body, the easier it is for your body to deal with them. Choose alcohols low in congener (“con-geen-er”) content, which are the toxins naturally created by the fermentation and aging processes of alcoholic beverages caused by the breakdown of the organic materials used to make the beverages. Congeners include substances like methanol, isopentanol, and acetone. Congener content is particularly high in the darker liquors like bourbon whiskey. Cognac, tequila, brandy, and wines with robust tannin content are also high in congener content. Alcoholic beverages with low congener content include clear liquors like vodka, gin, and rum. Sleep. Then sleep more. Eat a good meal before drinking. Having food in your stomach slows alcohol absorption, reducing the wave of alcohol hitting your bloodstream quickly. Hydrate aggressively before, during, and after drinking alcohol. Water is critical to help your body’s natural processes function smoothly.

How can I minimize hangover symptoms if I drank too much?

If you wake up with hangover symptoms, then take four capsules of Zero HD™ as soon as you wake up. Although you are behind the curve at that point, the ZeroHD™ will accelerate your recovery and reduce prolonged suffering and toxicity by supporting your body’s own efforts to rebalance itself.* Hydrate. Because alcohol is a diuretic, even moderate social drinking can lead to dehydration. Rehydrating is critical to supporting your body’s normal functioning. Eat a healthy breakfast (or lunch . . . or dinner if you took the advice to sleep more). Consider taking additional nutritional supplements beyond Zero Hour Detox™, such as: N-Acetyl-Cysteine (NAC) – NAC is a precursor to glutathione production. Although NAC does not provide direct, highly absorbable glutathione the way ZeroHD™ does, NAC facilitates your body’s efforts to make its own glutathione. Unfortunately, NAC is most helpful when taken before you start drinking, rather than after you stop drinking. Milk Thistle – This well-known botanical is widely regarded for its natural antioxidant powers, and is beneficial for supporting liver function. Magnesium – Minerals can be depleted by alcohol consumption. This essential mineral supports your body’s effort to fight inflammation, which is valuable after drinking. Signs of a magnesium deficiency include confusion, insomnia, apathy, weakness, and loss of appetite. B Vitamins – Alcohol consumption depletes all of the body’s B vitamins, which can lead to a long list of physical and mental complications, including disruption of neurotransmitter activity in the brain. Vitamin C – This vitamin is valuable in helping to reduce the oxidative stress that alcohol consumption places on the liver.

How does Zero Hour Detox™ help?

Instead of letting your body run out of its Master Antioxidant – glutathione – after just your first drink, Zero Hour Detox™ helps maintains this critical antioxidant through a direct, highly bioavailable dose.* The glutathione is able to bond with acetaldehyde, converting it to less-toxic acetate and reducing damage to your systems.* The more glutathione you have available (thanks to using ZeroHD™), the faster your body will be able to metabolize acetaldehyde and minimize its toxicity in your body.*

What’s different about Zero Hour Detox™?

You’ve never had a product before that addresses the effects of alcohol consumption the way Zero Hour Detox™ does.* We start with only glutathione and nothing else, the critical antioxidant your body needs when you start consuming alcohol. Next, we deliver the glutathion in a unique and powerful way to assure its optimal absorption and utilization.* We have licensed the most advanced nutrient delivery technology available from life sciences innovator Tesseract Medical Research®. The Tesseract Effect™ assures optimal delivery of every capsule of ZeroHD™. By locking each individual molecule of glutathione in its own individual carrier, Tesseract’s CyLoc™ and DexKey™ technologies assure that each molecule is transported, delivered, and absorbed individually for maximum benefit.*

What about other hangover relief product ingredients?

Some have marginal value. Many have no value. We believe that those which have some marginal value are useful because they encourage the pathway to glutathione production – but glutathione precursors will never have as much value as glutathione itself that is effectively and expeditiously delivered in the body.* Those hangover relief products with marginal value are supplying precursors to glutathione with the logic they will assist your body’s ability to make glutathione on its own. But there are several weaknesses to this theory, including the sub-par absorption of these precursors, the inefficient conversion of these precursors by your body as they “push” for glutathione production, and the lag time between ingesting the product and the marginal glutathione production that may occur. When your body needs water, you drink water – not a container of hydrogen and a container of oxygen with the intent of waiting for your body to make water from these two ingredients. When your body needs to detox from the effects of alcohol, you take the highly bioavailable glutathione in Zero Hour Detox™, not precursors that may or may not result in actual glutathione production.*

What’s so special about The Tesseract Effect™?

Zero Hour Detox™ has licensed the most innovative, patent pending nutrient delivery technology available from life sciences innovator Tesseract Medical Research®. Zero Hour Detox™ brings Tesseract’s medical market nutrient delivery science to a consumer product audience for the first time and on an exclusive basis. The Tesseract Effect™ refers to the uniquely powerful and synergistic performance of a supplement’s ingredients. After your first use, you’ll understand. Don’t take our word for it, just try ZeroHD™ head-to-head against any alcohol recovery product available.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease